At present, there are two kinds of studies on itaconate: Irg1−/− macrophages and the regulatory effect of itaconate derivatives. These two results were being complementary and disclosed that the regulatory mechanisms of itaconate associated alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription variab

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The interaction concerning host immune method and indigenous gut microbiota is connected to the pathogenesis of IBD [seventy five]. After gut microbiota is loss of homeostasis, the immune and metabolic capabilities of gastrointestinal tract could possibly be afflicted, bringing about inflammatory response and host mobile hurt. In rectal mucosa of p